| http://purl.uniprot.org/citations/12867986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12867986 | http://www.w3.org/2000/01/rdf-schema#comment | "Mechanical forces on matrix-integrin-cytoskeleton linkages are crucial for cell viability, morphology and organ function. The production of force depends on the molecular connections from extracellular-matrix-integrin complexes to the cytoskeleton. The minimal matrix complex causing integrin-cytoskeleton connections is a trimer of fibronectin's integrin-binding domain FNIII7-10 (ref. 4). Here we report a specific, molecular slip bond that was broken repeatedly by a force of 2 pN at the cellular loading rate of 60 nm x s(-1); this occurred with single trimer beads but not with monomer. Talin1, which binds to both integrins and actin filaments in vitro, is required for the 2-pN slip bond and rapid cytoskeleton binding. Further, inhibition of fibronectin binding to alpha(v)beta3 and deletion of beta3 markedly decreases the 2-pN force peak. We suggest that talin1 initially forms a molecular slip bond between closely packed fibronectin-integrin complexes and the actin cytoskeleton, which can apply a low level of force to fibronectin until many bonds form or a signal is received to activate a force response."xsd:string |
| http://purl.uniprot.org/citations/12867986 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01805"xsd:string |
| http://purl.uniprot.org/citations/12867986 | http://purl.uniprot.org/core/author | "Critchley D.R."xsd:string |
| http://purl.uniprot.org/citations/12867986 | http://purl.uniprot.org/core/author | "Jiang G."xsd:string |
| http://purl.uniprot.org/citations/12867986 | http://purl.uniprot.org/core/author | "Sheetz M.P."xsd:string |
| http://purl.uniprot.org/citations/12867986 | http://purl.uniprot.org/core/author | "Fukumoto E."xsd:string |
| http://purl.uniprot.org/citations/12867986 | http://purl.uniprot.org/core/author | "Giannone G."xsd:string |
| http://purl.uniprot.org/citations/12867986 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12867986 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/12867986 | http://purl.uniprot.org/core/pages | "334-337"xsd:string |
| http://purl.uniprot.org/citations/12867986 | http://purl.uniprot.org/core/title | "Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin."xsd:string |
| http://purl.uniprot.org/citations/12867986 | http://purl.uniprot.org/core/volume | "424"xsd:string |
| http://purl.uniprot.org/citations/12867986 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12867986 |
| http://purl.uniprot.org/citations/12867986 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12867986 |
| http://purl.uniprot.org/uniprot/P11276#attribution-C866C5515F294A00CA0C6D1DA37EDAB9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12867986 |
| http://purl.uniprot.org/uniprot/P11688#attribution-C866C5515F294A00CA0C6D1DA37EDAB9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12867986 |
| http://purl.uniprot.org/uniprot/O54890#attribution-C866C5515F294A00CA0C6D1DA37EDAB9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12867986 |
| http://purl.uniprot.org/uniprot/P26039#attribution-8F32329C56BAC443ED1F85589B24ACC2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12867986 |
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| http://purl.uniprot.org/uniprot/#_A0A087WS99-mappedCitation-12867986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12867986 |
| http://purl.uniprot.org/uniprot/#_A0A087WSN6-mappedCitation-12867986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12867986 |
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| http://purl.uniprot.org/uniprot/#_A0A087WR50-mappedCitation-12867986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12867986 |