| http://purl.uniprot.org/citations/12915450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12915450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12915450 | http://www.w3.org/2000/01/rdf-schema#comment | "The apolipoprotein A5 gene (APOA5 ) has been shown to play an important role in determining plasma triglyceride concentrations in humans. We describe here a novel variant, c.553G>T, in the apolipoprotein A5 gene that is associated with hypertriglyceridemia. In contrast to some other polymorphisms, which occur in non-coding regions of the gene, this variant occurs within the coding region and causes the change of amino acid sequence (a substitution of a cysteine for a glycine residue). The minor allele frequencies were 0.042 and 0.27 (P<0.001) for control and hypertriglyceridemic patients, respectively. The serum triglyceride level was significantly different among the genotypic groups (G/G 92.5+/-37.8 mg/dl, G/T 106.6+/-34.8 mg/dl, T/T 183.0 mg/dl, P=0.014) in control subjects. Multiple logistic regression revealed individuals carrying the minor allele had age, gender and BMI (body mass index)-adjusted odds ratio of 11.73 (95% confidence interval of 6.617-20.793; P<0.0001) for developing hypertriglyceridemia in comparison to individuals without that allele. These findings suggest the possible use of c.553G>T polymorphisms in APOA5 as prognostic indicators for hypertriglyceridemia susceptibility in Chinese."xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddg255"xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddg255"xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/author | "Hsu H.-C."xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/author | "Hsu H.-C."xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/author | "Chien K.-L."xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/author | "Chien K.-L."xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/author | "Kao J.-T."xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/author | "Kao J.-T."xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/author | "Lin S.-W."xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/author | "Lin S.-W."xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/author | "Wen H.-C."xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/author | "Wen H.-C."xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/pages | "2533-2539"xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/pages | "2533-2539"xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/title | "A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia."xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/title | "A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia."xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/12915450 | http://purl.uniprot.org/core/volume | "12"xsd:string |