| http://purl.uniprot.org/citations/12960175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12960175 | http://www.w3.org/2000/01/rdf-schema#comment | "CITED2 (CBP/p300-interacting transactivator with ED-rich tail 2) is a member of the Cited family of nuclear regulators, previously known as mrg1 (melanocyte-specific gene-related gene 1). CITED2 is inducible by varying stimuli including lipopolysaccharide, hypoxia, and cytokines such as interleukin 9 and interferon gamma. Using the immortalized human chondrocyte cell line, C-28/I2, we investigated whether CITED2 could be responsive to mechanical stimuli, and if so, whether CITED2 could mediate shear-driven regulation of matrix metalloproteinase (MMP) genes. The C-28/I2 cells were cultured under flow shear at 1-20 dyn/cm2, and the role of CIT-ED2 in regulation of MMPs was examined using the plasmids encoding sense and antisense CITED2 DNA sequences. The results showed that flow shear at 5 dyn/cm2 increased CITED2 mRNA and protein levels and down-regulated MMP-1 and MMP-13 mRNA and protein levels as well as enzyme activities. Consistent with the coordinated expression patterns of CITED2 and MMPs, overexpression of CITED2 repressed MMP-1 and MMP-13 mRNA levels and activities, whereas antisense CITED2 plasmids prevented the shear-induced down-regulation of MMP expression. Interleukin-1beta induced the formation of p300-Ets-1 complexes without affecting expression of CITED2. Transforming growth factor-beta as well as flow shear at 5 dyn/cm2 stimulated not only the expression of CITED2 but also the association of CIT-ED2 with p300 by dissociating Ets-1 from p300. These results indicate that CITED2 plays a major role in shear-induced down-regulation of MMP-1 and MMP-13 via a transforming growth factor-beta-dependent pathway."xsd:string |
| http://purl.uniprot.org/citations/12960175 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m304652200"xsd:string |
| http://purl.uniprot.org/citations/12960175 | http://purl.uniprot.org/core/author | "Yokota H."xsd:string |
| http://purl.uniprot.org/citations/12960175 | http://purl.uniprot.org/core/author | "Goldring M.B."xsd:string |
| http://purl.uniprot.org/citations/12960175 | http://purl.uniprot.org/core/author | "Sun H.B."xsd:string |
| http://purl.uniprot.org/citations/12960175 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12960175 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12960175 | http://purl.uniprot.org/core/pages | "47275-47280"xsd:string |
| http://purl.uniprot.org/citations/12960175 | http://purl.uniprot.org/core/title | "CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear."xsd:string |
| http://purl.uniprot.org/citations/12960175 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12960175 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12960175 |
| http://purl.uniprot.org/citations/12960175 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12960175 |
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