| http://purl.uniprot.org/citations/12970176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12970176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12970176 | http://www.w3.org/2000/01/rdf-schema#comment | "HHR23A, a protein implicated in nucleotide excision repair, belongs to a class of proteins containing both a ubiquitin-like (Ubl) domain and one or more ubiquitin-associated (UBA) domains, suggesting a role in the ubiquitin-proteasome pathway as well. The Ubl domain binds with high affinity to the second ubiquitin-interacting motif (UIM) of the S5a subunit of the proteasome. Here we present the solution structures of the HHR23A Ubl domain, the second UIM of S5a (UIM-2), and the Ubl:S5a-UIM-2 complex. The HHR23A Ubl domain is structurally similar to ubiquitin. The S5a UIM forms an alpha-helix with an unexpected hairpin loop that contributes to the binding interface with Ubl. The molecular determinants of the Ubl-proteasome interaction are revealed by analysis of the structures, chemical shift mapping, mutant binding studies and sequence conservation."xsd:string |
| http://purl.uniprot.org/citations/12970176 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg467"xsd:string |
| http://purl.uniprot.org/citations/12970176 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg467"xsd:string |
| http://purl.uniprot.org/citations/12970176 | http://purl.uniprot.org/core/author | "Feigon J."xsd:string |
| http://purl.uniprot.org/citations/12970176 | http://purl.uniprot.org/core/author | "Feigon J."xsd:string |
| http://purl.uniprot.org/citations/12970176 | http://purl.uniprot.org/core/author | "Mueller T.D."xsd:string |
| http://purl.uniprot.org/citations/12970176 | http://purl.uniprot.org/core/author | "Mueller T.D."xsd:string |
| http://purl.uniprot.org/citations/12970176 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12970176 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12970176 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12970176 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12970176 | http://purl.uniprot.org/core/pages | "4634-4645"xsd:string |
| http://purl.uniprot.org/citations/12970176 | http://purl.uniprot.org/core/pages | "4634-4645"xsd:string |
| http://purl.uniprot.org/citations/12970176 | http://purl.uniprot.org/core/title | "Structural determinants for the binding of ubiquitin-like domains to the proteasome."xsd:string |
| http://purl.uniprot.org/citations/12970176 | http://purl.uniprot.org/core/title | "Structural determinants for the binding of ubiquitin-like domains to the proteasome."xsd:string |
| http://purl.uniprot.org/citations/12970176 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12970176 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12970176 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12970176 |
| http://purl.uniprot.org/citations/12970176 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12970176 |
| http://purl.uniprot.org/citations/12970176 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12970176 |
| http://purl.uniprot.org/citations/12970176 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12970176 |
| http://purl.uniprot.org/uniprot/P54725 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12970176 |
| http://purl.uniprot.org/uniprot/P55036 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12970176 |