| http://purl.uniprot.org/citations/12970181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12970181 | http://www.w3.org/2000/01/rdf-schema#comment | "The genetic inactivation of the atypical protein kinase C (aPKC) inhibitor, Par-4, gives rise to increased NF-kappaB activation and decreased stimulation of JNK in embryo fibroblasts. Here we have characterized the immunological phenotype of the Par-4(-/-) mice and found that the loss of this gene leads to an increased proliferative response of peripheral T cells when challenged through the TCR. This is accompanied by a higher increase in cell cycle entry and inhibition of apoptosis, with enhanced IL-2 secretion but normal CD25 synthesis. Interestingly, the TCR-triggered activation of NF-kappaB was augmented and that of JNK was severely abrogated. Consistent with previous data from knock outs of different JNKs, NFATc1 activation and IL-4 secretion were augmented in the Par-4-deficient CD4+ T cells, suggesting that the loss of Par-4 drives T-cell differentiation towards a Th2 response. This is compelling evidence that Par-4 is a novel modulator of the immune response through its ability to impact aPKC activity, which translates into lower JNK signaling."xsd:string |
| http://purl.uniprot.org/citations/12970181 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdg460"xsd:string |
| http://purl.uniprot.org/citations/12970181 | http://purl.uniprot.org/core/author | "Serrano M."xsd:string |
| http://purl.uniprot.org/citations/12970181 | http://purl.uniprot.org/core/author | "Lafuente M.J."xsd:string |
| http://purl.uniprot.org/citations/12970181 | http://purl.uniprot.org/core/author | "Martin P."xsd:string |
| http://purl.uniprot.org/citations/12970181 | http://purl.uniprot.org/core/author | "Diaz-Meco M.T."xsd:string |
| http://purl.uniprot.org/citations/12970181 | http://purl.uniprot.org/core/author | "Moscat J."xsd:string |
| http://purl.uniprot.org/citations/12970181 | http://purl.uniprot.org/core/author | "Garcia-Cao I."xsd:string |
| http://purl.uniprot.org/citations/12970181 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12970181 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/12970181 | http://purl.uniprot.org/core/pages | "4689-4698"xsd:string |
| http://purl.uniprot.org/citations/12970181 | http://purl.uniprot.org/core/title | "Regulation of mature T lymphocyte proliferation and differentiation by Par-4."xsd:string |
| http://purl.uniprot.org/citations/12970181 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12970181 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12970181 |
| http://purl.uniprot.org/citations/12970181 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12970181 |
| http://purl.uniprot.org/uniprot/P25799#attribution-9788D6B0D197C908797E330E0827A1EC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12970181 |
| http://purl.uniprot.org/uniprot/Q925B0#attribution-38F5CA043B45F306989BB72B59EA46D7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12970181 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK6-mappedCitation-12970181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12970181 |
| http://purl.uniprot.org/uniprot/#_D3Z1Z4-mappedCitation-12970181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12970181 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPL3-mappedCitation-12970181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12970181 |
| http://purl.uniprot.org/uniprot/#_A3KBF5-mappedCitation-12970181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12970181 |
| http://purl.uniprot.org/uniprot/#_A6P3E4-mappedCitation-12970181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12970181 |
| http://purl.uniprot.org/uniprot/#_B5B2N2-mappedCitation-12970181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12970181 |
| http://purl.uniprot.org/uniprot/#_B5B2N4-mappedCitation-12970181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12970181 |