| http://purl.uniprot.org/citations/1378446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1378446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1378446 | http://www.w3.org/2000/01/rdf-schema#comment | "We have examined the subcellular localization of p60c-src in mammalian fibroblasts. Analysis of indirect immunofluorescence by three-dimensional optical sectioning microscopy revealed a granular cytoplasmic staining that co-localized with the microtubule organizing center. Immunofluorescence experiments with antibodies against a number of membrane markers demonstrated a striking co-localization between p60c-src and the cation-dependent mannose-6-phosphate receptor (CI-MPR), a marker that identifies endosomes. Both p60c-src and the CI-MPR were found to cluster at the spindle poles throughout mitosis. In addition, treatment of interphase and mitotic cells with brefeldin A resulted in a clustering of p60c-src and CI-MPR at a peri-centriolar position. Biochemical fractionation of cellular membranes showed that a major proportion of p60c-src co-enriched with endocytic membranes. Treatment of membranes containing HRP to alter their apparent density also altered the density of p60c-src-containing membranes. Similar density shift experiments with total cellular membranes revealed that the majority of membrane-associated p60c-src in the cell is associated with endosomes, while very little is associated with plasma membranes. These results support a role for p60c-src in the regulation of endosomal membranes and protein trafficking."xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.118.2.321"xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.118.2.321"xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/author | "Varmus H.E."xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/author | "Varmus H.E."xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/author | "Morgan D.O."xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/author | "Morgan D.O."xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/author | "Swedlow J.R."xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/author | "Swedlow J.R."xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/author | "Kaplan K.B."xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/author | "Kaplan K.B."xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/pages | "321-333"xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/pages | "321-333"xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/title | "Association of p60c-src with endosomal membranes in mammalian fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/title | "Association of p60c-src with endosomal membranes in mammalian fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/1378446 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1378446 |
| http://purl.uniprot.org/citations/1378446 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1378446 |