| http://purl.uniprot.org/citations/1386289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1386289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1386289 | http://www.w3.org/2000/01/rdf-schema#comment | "The mutant human cell line 11.1 is unresponsive to interferon alpha. Here we describe the genetic complementation of this mutant and the identification and cloning of the wild-type gene that corrects the defect. Using transfection with genomic DNA in conjunction with a powerful back-selection, we isolated a cosmid that reverts the mutant phenotype of 11.1 cells. The cosmid encodes a single message whose level is greatly reduced in mutant cells. Complementary DNAs were cloned and found to be virtually identical to tyk2, a human mRNA encoding a non-receptor protein tyrosine kinase of previously unknown function. This finding shows that tyk2 links the interferon alpha/beta receptor to the cytoplasmic transcription factor that mediates activation of interferon-responsive genes."xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(92)90105-l"xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(92)90105-l"xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/author | "Stark G.R."xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/author | "Stark G.R."xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/author | "Fellous M."xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/author | "Fellous M."xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/author | "Pellegrini S."xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/author | "Pellegrini S."xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/author | "Velazquez L."xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/author | "Velazquez L."xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/pages | "313-322"xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/pages | "313-322"xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/title | "A protein tyrosine kinase in the interferon alpha/beta signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/title | "A protein tyrosine kinase in the interferon alpha/beta signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/1386289 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1386289 |
| http://purl.uniprot.org/citations/1386289 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1386289 |