| http://purl.uniprot.org/citations/1423624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1423624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1423624 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified a human homolog of the Drosophila trithorax protein that is structurally altered by 11q23 translocations in acute leukemias. Human trithorax (HRX) is a predicted 431 kd protein containing two potential DNA-binding motifs consisting of zinc fingers conserved with the fly protein and nonconserved amino-terminal "AT hook" motifs related to the DNA-binding motifs in HMG proteins. 11q23 translocations disrupt the HRX gene between these two motifs, and in a t(11;19)-carrying cell line fusion transcripts are expressed from both derivative chromosomes. The more abundant derivative 11 transcript codes for a chimeric protein containing the AT hook motifs fused to a previously undescribed protein (ENL) from chromosome 19. These data suggest a novel role for a trithorax-homologous protein in multilineage human leukemias that may be mediated by DNA binding within the minor groove at AT-rich sites, implicated to play an important role in bacterial IHF-, yeast datin-, and mammalian HMG-mediated gene activation."xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(92)90602-9"xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(92)90602-9"xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/author | "Cleary M.L."xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/author | "Cleary M.L."xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/author | "Tkachuk D.C."xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/author | "Tkachuk D.C."xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/author | "Kohler S."xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/author | "Kohler S."xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/pages | "691-700"xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/pages | "691-700"xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/title | "Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias."xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/title | "Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias."xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/1423624 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1423624 |
| http://purl.uniprot.org/citations/1423624 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1423624 |
| http://purl.uniprot.org/citations/1423624 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1423624 |
| http://purl.uniprot.org/citations/1423624 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1423624 |