| http://purl.uniprot.org/citations/1460054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1460054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1460054 | http://www.w3.org/2000/01/rdf-schema#comment | "The promoter regions of many interferon-inducible genes share a short DNA sequence motif, termed the interferon consensus sequence (ICS) to which several regulatory proteins bind. A murine cDNA which encodes an ICS binding protein has been reported (M-ICSBP). The cloning of the human homologue of ICSBP (H-ICSBP) is described. H-ICSBP shares high sequence homology with its murine cognate. The derived sequence of H-ICSBP reveals restricted homology within the first 120 amino acids to three other interferon regulatory factors, IRF-1, IRF-2, and ISGF3 gamma. Truncated ICSBP lacking the first 33 amino-terminal amino acids fails to bind to the ICS, indicating that at least part of the DNA binding domain is located within the well conserved amino terminus. H-ICSBP is expressed exclusively in cell lines of hematopoietic origin. The results of transient transfection assays carried out either in hematopoietic or nonhematopoietic cells suggest that ICSBP acts as a negative regulatory factor on ICS-containing promoters. Furthermore, either interferon-gamma (IFN-gamma) or IFN-beta can alleviate the repression mediated by ICSBP. Therefore, ICSBP may be involved in maintaining submaximal transcriptional activity of IFN-inducible genes in hematopoietic cells. IFN treatment would then alleviate repression allowing maximal transcriptional activity of these genes."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)74081-2"xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)74081-2"xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/author | "Appella E."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/author | "Appella E."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/author | "Sharf R."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/author | "Sharf R."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/author | "Ozato K."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/author | "Ozato K."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/author | "Driggers P.H."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/author | "Driggers P.H."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/author | "Weisz A."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/author | "Weisz A."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/author | "Levi B.-Z."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/author | "Levi B.-Z."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/author | "Marx P."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/author | "Marx P."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/pages | "25589-25596"xsd:string |
| http://purl.uniprot.org/citations/1460054 | http://purl.uniprot.org/core/pages | "25589-25596"xsd:string |