| http://purl.uniprot.org/citations/14661054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14661054 | http://www.w3.org/2000/01/rdf-schema#comment | "Beta-catenin is an essential element for the transcriptional activation of target genes in the Wnt signaling cascade and is also a cell adhesion molecule that couples with cadherins. Although plakoglobin (gamma-catenin), a closely related homologue of beta-catenin, is also known to be a cell adhesion molecule, its function as a transcriptional factor has not been revealed in detail. Using a human malignant mesothelioma cell line, NCI-H28, in which we have identified a homozygous deletion of the beta-catenin gene, we studied whether plakoglobin has a T-cell factor/lymphocyte enhancer factor (TCF/LEF) family-dependent transcriptional activity. Transfection with the wild-type plakoglobin expression vector induced accumulation of plakoglobin in the nucleus. Immunoprecipitation assay with cotransfection of plakoglobin and either TCF-4 or LEF-1 detected binding of plakoglobin to TCF-4 or LEF-1. Luciferase reporter assay demonstrated transcriptional activity of the wild-type plakoglobin when transfected with TCF/LEF, although plakoglobin showed less activity than beta-catenin. Exogenous plakoglobin was also shown to promote entrance of exogenous beta-catenin into the nuclei. Furthermore, small interfering RNA directed against plakoglobin suppressed expression of endogenous plakoglobin and its transcriptional activity, suggesting that endogenous plakoglobin has a weak transcriptional activity. These results suggest that plakoglobin can activate the Wnt signaling cascade directly without interaction of beta-catenin, and that plakoglobin has multiple functions as a transcriptional activator and a cell adhesion molecule like beta-catenin."xsd:string |
| http://purl.uniprot.org/citations/14661054 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1207254"xsd:string |
| http://purl.uniprot.org/citations/14661054 | http://purl.uniprot.org/core/author | "Goto H."xsd:string |
| http://purl.uniprot.org/citations/14661054 | http://purl.uniprot.org/core/author | "Kondo M."xsd:string |
| http://purl.uniprot.org/citations/14661054 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/14661054 | http://purl.uniprot.org/core/author | "Usami N."xsd:string |
| http://purl.uniprot.org/citations/14661054 | http://purl.uniprot.org/core/author | "Sekido Y."xsd:string |
| http://purl.uniprot.org/citations/14661054 | http://purl.uniprot.org/core/author | "Shimokata K."xsd:string |
| http://purl.uniprot.org/citations/14661054 | http://purl.uniprot.org/core/author | "Maeda O."xsd:string |
| http://purl.uniprot.org/citations/14661054 | http://purl.uniprot.org/core/author | "Kusugami K."xsd:string |
| http://purl.uniprot.org/citations/14661054 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14661054 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/14661054 | http://purl.uniprot.org/core/pages | "964-972"xsd:string |
| http://purl.uniprot.org/citations/14661054 | http://purl.uniprot.org/core/title | "Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line."xsd:string |
| http://purl.uniprot.org/citations/14661054 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/14661054 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14661054 |
| http://purl.uniprot.org/citations/14661054 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14661054 |
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