| http://purl.uniprot.org/citations/14662747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14662747 | http://www.w3.org/2000/01/rdf-schema#comment | "The novel Ras-like small GTPase Rin is expressed prominently in adult neurons, and binds calmodulin (CaM) through its COOH-terminal-binding motif. It might be involved in calcium/CaM-mediated neuronal signaling, but Rin-mediated signal transduction pathways have not yet been elucidated. Here, we show that expression of Rin induces neurite outgrowth without nerve growth factor or mitogen-activated protein kinase activation in rat pheochromocytoma PC12 cells. Rin-induced neurite outgrowth was markedly inhibited by coexpression with dominant negative Rac/Cdc42 protein or CaM inhibitor treatment. We also found that expression of Rin elevated the endogenous Rac/Cdc42 activity. Rin mutant proteins, in which the mutation disrupted association with CaM, failed to induce neurite outgrowth irrespective of Rac/Cdc42 activation. Disruption of endogenous Rin function inhibited the neurite outgrowth stimulated by forskolin and extracellular calcium entry through voltage-dependent calcium channel evoked by KCl. These findings suggest that Rin-mediated neurite outgrowth signaling requires not only endogenous Rac/Cdc42 activation but also Rin-CaM association, and that endogenous Rin is involved in calcium/CaM-mediated neuronal signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/14662747 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200308070"xsd:string |
| http://purl.uniprot.org/citations/14662747 | http://purl.uniprot.org/core/author | "Hoshino M."xsd:string |
| http://purl.uniprot.org/citations/14662747 | http://purl.uniprot.org/core/author | "Nakamura S."xsd:string |
| http://purl.uniprot.org/citations/14662747 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14662747 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/14662747 | http://purl.uniprot.org/core/pages | "1067-1076"xsd:string |
| http://purl.uniprot.org/citations/14662747 | http://purl.uniprot.org/core/title | "Small GTPase Rin induces neurite outgrowth through Rac/Cdc42 and calmodulin in PC12 cells."xsd:string |
| http://purl.uniprot.org/citations/14662747 | http://purl.uniprot.org/core/volume | "163"xsd:string |
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