| http://purl.uniprot.org/citations/14676304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14676304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14676304 | http://www.w3.org/2000/01/rdf-schema#comment | "Cylindromas are benign adnexal skin tumors caused by germline mutations in the CYLD gene. In most cases the second wild-type allele is lost in tumor tissue, suggesting that CYLD functions as tumor suppressor. CYLD is a protein of 956 amino acids harboring a functional deubiquitinating domain at the COOH-terminal end. To shed more light on the function of CYLD, we have performed a yeast two hybrid screen using an HaCaT cDNA library that identified the RING finger protein TRIP (TRAF-interacting protein) as interactor with full-length CYLD. Mapping of the interacting domains revealed that the central domain of CYLD binds to the COOH-terminal end of TRIP. Far Western analysis and coimmunoprecipitations in mammalian cells confirmed that full-length CYLD binds to the COOH-terminal domain of TRIP. Because TRIP is an inhibitor of nuclear factor (NF)-kappaB activation by tumor necrosis factor (TNF), the effect of CYLD on NF-kappaB activation was investigated in HeLa cells. The results established that CYLD down-regulates NF-kappaB activation by TNF-alpha. The inhibition by CYLD depends on the presence of the central domain interacting with TRIP and its deubiquitinating activity. These findings indicate that cylindromas arise through constitutive NF-kappaB activation leading to hyperproliferation and tumor growth."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20031187"xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20031187"xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/author | "Huber M."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/author | "Huber M."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/author | "Hohl D."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/author | "Hohl D."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/author | "Regamey A."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/author | "Regamey A."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/author | "Liu J.W."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/author | "Liu J.W."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/author | "Roger T."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/author | "Roger T."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/author | "Kogerman P."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/author | "Kogerman P."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/author | "Toftgaard R."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/author | "Toftgaard R."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/pages | "1959-1964"xsd:string |
| http://purl.uniprot.org/citations/14676304 | http://purl.uniprot.org/core/pages | "1959-1964"xsd:string |