| http://purl.uniprot.org/citations/14697667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14697667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14697667 | http://www.w3.org/2000/01/rdf-schema#comment | "Che-1 is a recently identified human Rb binding protein that inhibits the Rb growth-suppressing function and regulates cell proliferation. Che-1 contacts the Rb and competes with HDAC1 for Rb-binding site, removing HDAC1 from the Rb/E2F cell cycle-regulated promoters. We have investigated the expression of Che-1 in neuronal cells and we showed that Che-1 directly interacts with Tau. Tau is a microtubule-associated protein involved in the assembly and stabilization of neuronal microtubules network that plays a crucial role modulating neuronal morphogenesis, axonal shape, and transport. In rat cerebellar granule neurons (CGNs) Che-1 partially colocalizes with Tau in the cytoplasm. Che-1 binds the amino-terminal region of Tau protein, which is not involved in microtubule interactions. Tau and Che-1 endogenous proteins coimmunoprecipitate from CGNs cellular lysates. In addition, Che-1/Tau interaction was demonstrated both in overexpressing COS-7 cells and CGNs by FRET analysis. Finally, we observed that Tau/Che-1 interaction is modulated during neuronal apoptosis."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcn.2003.08.002"xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcn.2003.08.002"xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Amadoro G."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Amadoro G."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Barbato C."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Barbato C."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Bruno T."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Bruno T."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Calissano P."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Calissano P."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Canu N."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Canu N."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Ciotti M."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Ciotti M."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Corbi N."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Corbi N."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "De Angelis R."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "De Angelis R."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Fanciulli M."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Fanciulli M."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Libri V."xsd:string |
| http://purl.uniprot.org/citations/14697667 | http://purl.uniprot.org/core/author | "Libri V."xsd:string |