| http://purl.uniprot.org/citations/14729963 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14729963 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14729963 | http://www.w3.org/2000/01/rdf-schema#comment | "Human RNPS1 was originally purified and characterized as a pre-mRNA splicing activator, and its role in the postsplicing process has also been proposed recently. To search for factors that functionally interact with RNPS1, we performed a yeast two-hybrid screen with a human cDNA library. Four factors were identified: p54 (also called SRp54; a member of the SR protein family), human transformer 2 beta (hTra2 beta; an exonic splicing enhancer-binding protein), hLucA (a potential component of U1 snRNP), and pinin (also called DRS and MemA; a protein localized in nuclear speckles). The N-terminal region containing the serine-rich (S) domain, the central RNA recognition motif (RRM), and the C-terminal arginine/serine/proline-rich (RS/P) domain of RNPS1 interact with p54, pinin, and hTra2 beta, respectively. Protein-protein binding between RNPS1 and these factors was verified in vitro and in vivo. Overexpression of RNPS1 in HeLa cells induced exon skipping in a model beta-globin pre-mRNA and a human tra-2 beta pre-mRNA. Coexpression of RNPS1 with p54 cooperatively stimulated exon inclusion in an ATP synthase gamma-subunit pre-mRNA. The RS/P domain and RRM are necessary for the exon-skipping activity, whereas the S domain is important for the cooperative effect with p54. RNPS1 appears to be a versatile factor that regulates alternative splicing of a variety of pre-mRNAs."xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.3.1174-1187.2004"xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.3.1174-1187.2004"xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/author | "Werner D."xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/author | "Werner D."xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/author | "Endo H."xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/author | "Endo H."xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/author | "Mayeda A."xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/author | "Mayeda A."xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/author | "Sakashita E."xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/author | "Sakashita E."xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/author | "Tatsumi S."xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/author | "Tatsumi S."xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/pages | "1174-1187"xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/pages | "1174-1187"xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/title | "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo."xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/title | "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo."xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/14729963 | http://purl.uniprot.org/core/volume | "24"xsd:string |