| http://purl.uniprot.org/citations/14734526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14734526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14734526 | http://www.w3.org/2000/01/rdf-schema#comment | "Base substitutions, deletions, and duplications are observed at the immunoglobulin locus in DNA sequences involved in class switch recombination (CSR). These mutations are dependent upon activation-induced cytidine deaminase (AID) and present all the characteristics of the ones observed during V gene somatic hypermutation, implying that they could be generated by the same mutational complex. It has been proposed, based on the V gene mutation pattern of patients with the cancer-prone xeroderma pigmentosum variant (XP-V) syndrome who are deficient in DNA polymerase eta (pol eta), that this enzyme could be responsible for a large part of the mutations occurring on A/T bases. Here we show, by analyzing switched memory B cells from two XP-V patients, that pol eta is also an A/T mutator during CSR, in both the switch region of tandem repeats as well as upstream of it, thus suggesting that the same error-prone translesional polymerases are involved, together with AID, in both processes."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20031831"xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20031831"xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Weller S."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Weller S."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Sarasin A."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Sarasin A."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Vuillier F."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Vuillier F."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Reynaud C.-A."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Reynaud C.-A."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Weill J.-C."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Weill J.-C."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Aoufouchi S."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Aoufouchi S."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Faili A."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Faili A."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Stary A."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/author | "Stary A."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/14734526 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |