| http://purl.uniprot.org/citations/14739254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14739254 | http://www.w3.org/2000/01/rdf-schema#comment | "Liver X receptors (LXRs) regulate the expression of a number of genes involved in cholesterol and lipid metabolism after activation by their cognate oxysterol ligands. AKR1-B7 (aldo-keto reductase 1-B7) is expressed in LXR target tissues such as intestine, and because of its known role in detoxifying lipid peroxides, we investigated whether the AKR1-B7 detoxification pathway was regulated by LXRs. Here we show that synthetic LXR agonists increase the accumulation of AKR1-B7 mRNA and protein levels in mouse intestine in wild-type but not lxr(-/-) mice. Regulation of akr1b7 by retinoic X receptor/LXR heterodimers is dependent on three response elements in the proximal murine akr1b7 promoter. Two of these cis-acting elements are specific for regulation by the LXRalpha isoform. In addition, in duodenum of wild-type mice fed a synthetic LXR agonist, we observed an LXR-dependent decrease in lipid peroxidation. Our results demonstrate that akr1b7 is a direct target of LXRs throughout the small intestine, and that LXR activation plays a protective role by decreasing the deleterious effects of lipid peroxides in duodenum. Taken together, these data suggest a new role for LXRs in lipid detoxification."xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2003-0338"xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://purl.uniprot.org/core/author | "Mangelsdorf D.J."xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://purl.uniprot.org/core/author | "Repa J.J."xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://purl.uniprot.org/core/author | "Veyssiere G."xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://purl.uniprot.org/core/author | "Mazur A."xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://purl.uniprot.org/core/author | "Val P."xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://purl.uniprot.org/core/author | "Cummins C.L."xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://purl.uniprot.org/core/author | "Caira F."xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://purl.uniprot.org/core/author | "Henry-Berger J."xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://purl.uniprot.org/core/author | "Lobaccaro J.M."xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://purl.uniprot.org/core/author | "Volle D.H."xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14739254 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://purl.uniprot.org/core/pages | "888-898"xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://purl.uniprot.org/core/title | "Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes."xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/14739254 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14739254 |
| http://purl.uniprot.org/citations/14739254 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14739254 |
| http://purl.uniprot.org/uniprot/P21300#attribution-C38C85516782D206031EF4C16CEA4E21 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14739254 |
| http://purl.uniprot.org/uniprot/Q9Z0Y9#attribution-9BBB720E41D58619C8388CE5E38ECA4E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14739254 |
| http://purl.uniprot.org/uniprot/Q60644#attribution-9BBB720E41D58619C8388CE5E38ECA4E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14739254 |
| http://purl.uniprot.org/uniprot/#_A0A140LHK8-mappedCitation-14739254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14739254 |
| http://purl.uniprot.org/uniprot/#_A0A140LHL9-mappedCitation-14739254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14739254 |