| http://purl.uniprot.org/citations/14754897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14754897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14754897 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor NFkappaB plays important roles in immune regulation, inflammatory responses, and anti-apoptosis. Activation of NFkappaB requires the activity of IkappaB kinase, a kinase complex that contains two catalytic subunits, IKKalpha and IKKbeta, and a non-enzymatic regulatory subunit, IKKgamma. To understand how NFkappaB activation is regulated at the IKKgamma level, we searched for IKKgamma-interacting proteins by the yeast two-hybrid system. This search identified ZNF216, a zinc finger protein with unknown biological functions. ZNF216 contains an A20-like zinc finger domain (ZnF-A20) at its N terminus and an AN1-like domain (ZnF-AN1) at its C terminus. Similar to A20, ZNF216 interacted with IKKgamma, RIP, and TRAF6 in co-immunoprecipitation experiments. Domain mapping experiments indicated that the ZnF-A20 domain was responsible for interacting with IKKgamma and RIP, whereas the ZnF-AN1 domain interacted with TRAF6. ZNF216 inhibited NFkappaB activation triggered by overexpression of RIP and TRAF6 but not of p65. ZNF216 also inhibited tumor necrosis factor (TNF)-, interleukin-1-, and Toll-like receptor 4-induced NFkappaB activation in a dose-dependent manner. The ZnF-A20 domain was essential for ZNF216-mediated inhibition of NFkappaB activation. The ZnF-A20 and ZnF-AN1 domains of ZNF216 could interact with each other, whereas ZNF216 could form homo-oligomers or hetero-oligomers with A20. Unlike A20, which inhibits TNF-induced apoptosis, overexpression of ZNF216 sensitized cells to TNF-induced apoptosis. Our findings suggest that ZNF216 and A20 have redundant and distinct roles in regulating NFkappaB activation and apoptosis."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m309491200"xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m309491200"xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Chen D."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Chen D."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Li L.'"xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Li L.'"xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Teng L."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Teng L."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Zhai Z."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Zhai Z."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Xu L.-G."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Xu L.-G."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Shu H.-B."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/author | "Shu H.-B."xsd:string |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14754897 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |