| http://purl.uniprot.org/citations/14764811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14764811 | http://www.w3.org/2000/01/rdf-schema#comment | "We sequenced the promoter and coding regions of PCK1 encoding cytosolic phosphoenolpyruvate carboxykinase from genomic DNA of subjects with type 2 diabetes mellitus (DM). We found nine single nucleotide polymorphisms (SNPs) that were present with varying allele frequencies and pairwise linkage disequilibrium relationships in different ethnic groups. The -232C-->G promoter SNP was within a cis-acting element required for basal and cAMP-mediated PCK1 gene transcription. The expression of a luciferase reporter construct containing -232G in three different cell lines showed significantly increased basal expression with no down-regulation by insulin compared with a construct containing -232C. The odds ratios for type 2 DM among subjects with one or two copies of -232G compared with -232C/C homozygotes were 1.9 (95% confidence interval, 1.2-3.0) in a Canadian aboriginal sample and 2.8 (95% confidence interval, 1.7-4.7) in a Caucasian sample. Thus, we report a promoter SNP in PCK1 that was resistant to down-regulation by insulin in vitro and was associated with type 2 DM in two independent study samples."xsd:string |
| http://purl.uniprot.org/citations/14764811 | http://purl.org/dc/terms/identifier | "doi:10.1210/jc.2003-031361"xsd:string |
| http://purl.uniprot.org/citations/14764811 | http://purl.uniprot.org/core/author | "Cao H."xsd:string |
| http://purl.uniprot.org/citations/14764811 | http://purl.uniprot.org/core/author | "Harris S.B."xsd:string |
| http://purl.uniprot.org/citations/14764811 | http://purl.uniprot.org/core/author | "Hegele R.A."xsd:string |
| http://purl.uniprot.org/citations/14764811 | http://purl.uniprot.org/core/author | "Zinman B."xsd:string |
| http://purl.uniprot.org/citations/14764811 | http://purl.uniprot.org/core/author | "Pickering J.G."xsd:string |
| http://purl.uniprot.org/citations/14764811 | http://purl.uniprot.org/core/author | "Young T.K."xsd:string |
| http://purl.uniprot.org/citations/14764811 | http://purl.uniprot.org/core/author | "Ban M.R."xsd:string |
| http://purl.uniprot.org/citations/14764811 | http://purl.uniprot.org/core/author | "Hanley A.J."xsd:string |
| http://purl.uniprot.org/citations/14764811 | http://purl.uniprot.org/core/author | "van der Veer E."xsd:string |
| http://purl.uniprot.org/citations/14764811 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14764811 | http://purl.uniprot.org/core/name | "J Clin Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/14764811 | http://purl.uniprot.org/core/pages | "898-903"xsd:string |
| http://purl.uniprot.org/citations/14764811 | http://purl.uniprot.org/core/title | "Promoter polymorphism in PCK1 (phosphoenolpyruvate carboxykinase gene) associated with type 2 diabetes mellitus."xsd:string |
| http://purl.uniprot.org/citations/14764811 | http://purl.uniprot.org/core/volume | "89"xsd:string |
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