| http://purl.uniprot.org/citations/1487136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1487136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1487136 | http://www.w3.org/2000/01/rdf-schema#comment | "Human apolipoprotein A-IV (apoA-IV) exhibits a genetically determined structural polymorphism amenable to analysis by isoelectric focusing and immunoblotting techniques. We have determined the allele frequency and molecular basis of a unique ApoA-IV*5 allele which is widely distributed among blacks but is absent in other populations. The frequency of the ApoA-IV*5 allele in blacks (N = 308) was estimated to be 3.2%. In comparison to the common ApoA-IV*1 allele, analysis of coding and non-coding sequences of the ApoA-IV*5 allele revealed an in-frame insertion of 12 nucleotides near the carboxyl terminal region of the mature protein. The insertion involves an exact duplication of the second of the four repeats and codes for 4 amino acids glutamic acid (GAA), glutamine (CAG), glutamine (CAG), and glutamine (CAG) and is responsible for the charge shift of the the apoA-IV 5 isoform slightly toward the anode as compared to the wild type apoA-IV 1 isoform on the isoelectric focusing gel. This in-frame insertion occurs in a region which is highly conserved among rat, mouse, and humans. In addition to the 12 nucleotide insertion, the four individuals sequenced for the ApoA-IV*5 allele also revealed a same-sense mutation by replacing G to T at the third position of codon 316. Our preliminary data suggest that this unique black allele marker may be of potentially significance in studies of human lipid metabolism and in microevolution."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.org/dc/terms/identifier | "doi:10.1002/gepi.1370090602"xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.org/dc/terms/identifier | "doi:10.1002/gepi.1370090602"xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/author | "Williams E.R."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/author | "Williams E.R."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/author | "Kamboh M.I."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/author | "Kamboh M.I."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/author | "Law J.C."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/author | "Law J.C."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/author | "Ferrell R.E."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/author | "Ferrell R.E."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/author | "Aston C.E."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/author | "Aston C.E."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/author | "Bunker C.H."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/author | "Bunker C.H."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/author | "Pollitzer W.S."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/author | "Pollitzer W.S."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/name | "Genet. Epidemiol."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/name | "Genet. Epidemiol."xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/pages | "379-388"xsd:string |
| http://purl.uniprot.org/citations/1487136 | http://purl.uniprot.org/core/pages | "379-388"xsd:string |