| http://purl.uniprot.org/citations/14980210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14980210 | http://www.w3.org/2000/01/rdf-schema#comment | "To identify the molecular mechanisms underlying psychostimulant-elicited plasticity in the brain reward system, we undertook a phenotype-driven approach using genome-wide microarray profiling of striatal transcripts from three genetic and one pharmacological mouse models of psychostimulant or dopamine supersensitivity. A small set of co-affected genes was identified. One of these genes encoding the synaptic scaffolding protein PSD-95 is downregulated in the striatum of all three mutants and in chronically, but not acutely, cocaine-treated mice. At the synaptic level, enhanced long-term potentiation (LTP) of the frontocortico-accumbal glutamatergic synapses correlates with PSD-95 reduction in every case. Finally, targeted deletion of PSD-95 in an independent line of mice enhances LTP, augments the acute locomotor-stimulating effects of cocaine, but leads to no further behavioral plasticity in response to chronic cocaine. Our findings uncover a previously unappreciated role of PSD-95 in psychostimulant action and identify a molecular and cellular mechanism shared between drug-related plasticity and learning."xsd:string |
| http://purl.uniprot.org/citations/14980210 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(04)00048-0"xsd:string |
| http://purl.uniprot.org/citations/14980210 | http://purl.uniprot.org/core/author | "Caron M.G."xsd:string |
| http://purl.uniprot.org/citations/14980210 | http://purl.uniprot.org/core/author | "Grant S.G."xsd:string |
| http://purl.uniprot.org/citations/14980210 | http://purl.uniprot.org/core/author | "Gainetdinov R.R."xsd:string |
| http://purl.uniprot.org/citations/14980210 | http://purl.uniprot.org/core/author | "Sotnikova T.D."xsd:string |
| http://purl.uniprot.org/citations/14980210 | http://purl.uniprot.org/core/author | "Cyr M."xsd:string |
| http://purl.uniprot.org/citations/14980210 | http://purl.uniprot.org/core/author | "Beaulieu J.M."xsd:string |
| http://purl.uniprot.org/citations/14980210 | http://purl.uniprot.org/core/author | "Torres G.E."xsd:string |
| http://purl.uniprot.org/citations/14980210 | http://purl.uniprot.org/core/author | "Yao W.D."xsd:string |
| http://purl.uniprot.org/citations/14980210 | http://purl.uniprot.org/core/author | "Arbuckle M.I."xsd:string |
| http://purl.uniprot.org/citations/14980210 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14980210 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/14980210 | http://purl.uniprot.org/core/pages | "625-638"xsd:string |
| http://purl.uniprot.org/citations/14980210 | http://purl.uniprot.org/core/title | "Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity."xsd:string |
| http://purl.uniprot.org/citations/14980210 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/14980210 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14980210 |
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