| http://purl.uniprot.org/citations/14988498 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14988498 | http://www.w3.org/2000/01/rdf-schema#comment | "The tumor necrosis factor (TNF) family member APRIL binds to the receptors BCMA on B cells and TACI on B and T cells. To investigate the role of APRIL in immunity, we generated APRIL-deficient mice. APRIL(-/-) mice have normal T and B lymphocyte development, normal T and B cell proliferation in vitro, but increased numbers of CD44(hi)CD62L(lo) CD4(+) effector/memory T cells and increased IgG responses to T-dependent antigens. Serum IgA levels were significantly decreased, and serum IgA antibody responses to mucosal immunization with TD antigens and to type 1 T-independent antigens were impaired in APRIL(-/-) mice. APRIL by itself induced IgA as well as IgG1 isotype switching in CD40-deficient IgM(+)IgD(+) sorted B cells. These results suggest that APRIL down-regulates T cell-dependent antibody responses and promotes IgA class switching."xsd:string |
| http://purl.uniprot.org/citations/14988498 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0307348101"xsd:string |
| http://purl.uniprot.org/citations/14988498 | http://purl.uniprot.org/core/author | "Bhan A.K."xsd:string |
| http://purl.uniprot.org/citations/14988498 | http://purl.uniprot.org/core/author | "Scott S."xsd:string |
| http://purl.uniprot.org/citations/14988498 | http://purl.uniprot.org/core/author | "Geha R.S."xsd:string |
| http://purl.uniprot.org/citations/14988498 | http://purl.uniprot.org/core/author | "Mizoguchi E."xsd:string |
| http://purl.uniprot.org/citations/14988498 | http://purl.uniprot.org/core/author | "Dedeoglu F."xsd:string |
| http://purl.uniprot.org/citations/14988498 | http://purl.uniprot.org/core/author | "Castigli E."xsd:string |
| http://purl.uniprot.org/citations/14988498 | http://purl.uniprot.org/core/author | "Jabara H."xsd:string |
| http://purl.uniprot.org/citations/14988498 | http://purl.uniprot.org/core/author | "Bryce P."xsd:string |
| http://purl.uniprot.org/citations/14988498 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14988498 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/14988498 | http://purl.uniprot.org/core/pages | "3903-3908"xsd:string |
| http://purl.uniprot.org/citations/14988498 | http://purl.uniprot.org/core/title | "Impaired IgA class switching in APRIL-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/14988498 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/14988498 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14988498 |
| http://purl.uniprot.org/citations/14988498 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14988498 |
| http://purl.uniprot.org/uniprot/P01868#attribution-4FBE3889D4FD51C9BA61443260A4D353 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14988498 |
| http://purl.uniprot.org/uniprot/P01872#attribution-4FBE3889D4FD51C9BA61443260A4D353 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14988498 |
| http://purl.uniprot.org/uniprot/P01867#attribution-4FBE3889D4FD51C9BA61443260A4D353 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14988498 |
| http://purl.uniprot.org/uniprot/P01869#attribution-4FBE3889D4FD51C9BA61443260A4D353 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14988498 |
| http://purl.uniprot.org/uniprot/P07750#attribution-4FBE3889D4FD51C9BA61443260A4D353 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14988498 |
| http://purl.uniprot.org/uniprot/P01137#attribution-4FBE3889D4FD51C9BA61443260A4D353 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14988498 |
| http://purl.uniprot.org/uniprot/Q9D777#attribution-88D02B0AE079A2CE533CBE537371FC2A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14988498 |