| http://purl.uniprot.org/citations/14992725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14992725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14992725 | http://www.w3.org/2000/01/rdf-schema#comment | "Human DNA polymerase lambda (Pol lambda) is a family X member with low frameshift fidelity that has been suggested to perform gap-filling DNA synthesis during base excision repair and during repair of broken ends with limited homology. Here, we present a 2.1 A crystal structure of the catalytic core of Pol lambda in complex with DNA containing a two nucleotide gap. Pol lambda makes limited contacts with the template strand at the polymerase active site, and superimposition with Pol beta in a ternary complex suggests a shift in the position of the DNA at the active site that is reminiscent of a deletion intermediate. Surprisingly, Pol lambda can adopt a closed conformation, even in the absence of dNTP binding. These observations have implications for the catalytic mechanism and putative DNA repair functions of Pol lambda."xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(04)00061-9"xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(04)00061-9"xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/author | "Bebenek K."xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/author | "Bebenek K."xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/author | "Kunkel T.A."xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/author | "Kunkel T.A."xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/author | "Blanco L."xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/author | "Blanco L."xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/author | "Garcia-Diaz M."xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/author | "Garcia-Diaz M."xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/author | "Pedersen L.C."xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/author | "Pedersen L.C."xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/author | "Krahn J.M."xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/author | "Krahn J.M."xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/pages | "561-572"xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/pages | "561-572"xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/title | "A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology."xsd:string |
| http://purl.uniprot.org/citations/14992725 | http://purl.uniprot.org/core/title | "A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology."xsd:string |