| http://purl.uniprot.org/citations/15010370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15010370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15010370 | http://www.w3.org/2000/01/rdf-schema#comment | "Aggregation of high-affinity receptors for immunoglobulin E (Fc epsilon RI) on the surface of mast cells results in degranulation, a response that is potentiated by binding of stem cell factor (SCF) to its receptor Kit. We observed that one of the major initial signaling events associated with Fc epsilon RI-mediated activation of human mast cells (HuMCs) is the rapid tyrosine phosphorylation of a protein of 25 to 30 kDa. The phosphorylation of this protein was also observed in response to SCF. This protein was identified as non-T-cell activation linker (NTAL), an adaptor molecule similar to linker for activated T cells (LAT). Unlike the Fc epsilon RI response, SCF induced NTAL phosphorylation in the absence of detectable LAT phosphorylation. When SCF and antigen were added concurrently, there was a marked synergistic effect on NTAL phosphorylation, however, SCF did not enhance the phosphorylation of LAT induced by Fc epsilon RI aggregation. Fc epsilon RI- and SCF-mediated NTAL phosphorylation appear to be differentially regulated by Src kinases and/or Kit kinase, respectively. Diminution of NTAL expression by silencing RNA oligonucleotides in HuMCs resulted in a reduction of both Kit- and Fc epsilon RI-mediated degranulation. NTAL, thus, appears to be an important link between the signaling pathways that are initiated by these receptors, culminating in mast cell degranulation."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-08-2769"xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-08-2769"xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Draber P."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Draber P."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Metcalfe D.D."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Metcalfe D.D."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Iwaki S."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Iwaki S."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Horejsi V."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Horejsi V."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Samelson L.E."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Samelson L.E."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Satterthwaite A.B."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Satterthwaite A.B."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Gilfillan A.M."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Gilfillan A.M."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Nahm D.H."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Nahm D.H."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Tkaczyk C."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/author | "Tkaczyk C."xsd:string |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15010370 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |