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| http://purl.uniprot.org/citations/15024080 | http://www.w3.org/2000/01/rdf-schema#comment | "Malignant melanoma, an aggressive and increasingly common cancer, is characterized by a strikingly high rate (70%) of mutations in BRAF, a key component of the mitogen-activated protein (MAP) kinase signaling pathway. How signaling events downstream from BRAF affect the underlying program of gene expression is poorly understood. We show that the Brn-2 POU domain transcription factor is highly expressed in melanoma cell lines but not in melanocytes or melanoblasts and that overexpression of Brn-2 in melanocytes results in increased proliferation. Expression of Brn-2 is strongly upregulated by Ras and MAP kinase signaling. Importantly, the Brn-2 promoter is stimulated by kinase-activating BRAF mutants and endogenous Brn-2 expression is inhibited by RNA interference-mediated downregulation of BRAF. Moreover, silent interfering RNA-mediated depletion of Brn-2 in melanoma cells expressing activated BRAF leads to decreased proliferation. The results suggest that the high levels of Brn-2 expression observed in melanomas link BRAF signaling to increased proliferation."xsd:string |
| http://purl.uniprot.org/citations/15024080 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.7.2923-2931.2004"xsd:string |
| http://purl.uniprot.org/citations/15024080 | http://purl.uniprot.org/core/author | "Roberts K."xsd:string |
| http://purl.uniprot.org/citations/15024080 | http://purl.uniprot.org/core/author | "Goodall J."xsd:string |
| http://purl.uniprot.org/citations/15024080 | http://purl.uniprot.org/core/author | "Goding C.R."xsd:string |
| http://purl.uniprot.org/citations/15024080 | http://purl.uniprot.org/core/author | "Marais R."xsd:string |
| http://purl.uniprot.org/citations/15024080 | http://purl.uniprot.org/core/author | "Wellbrock C."xsd:string |
| http://purl.uniprot.org/citations/15024080 | http://purl.uniprot.org/core/author | "Dexter T.J."xsd:string |
| http://purl.uniprot.org/citations/15024080 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15024080 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/15024080 | http://purl.uniprot.org/core/pages | "2923-2931"xsd:string |
| http://purl.uniprot.org/citations/15024080 | http://purl.uniprot.org/core/title | "The Brn-2 transcription factor links activated BRAF to melanoma proliferation."xsd:string |
| http://purl.uniprot.org/citations/15024080 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/15024080 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15024080 |
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