| http://purl.uniprot.org/citations/15063782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15063782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15063782 | http://www.w3.org/2000/01/rdf-schema#comment | "Axin, a negative regulator of Wnt, forms a complex with glycogen synthase kinase 3beta, beta-catenin, and adenomatous polyposis coli and promotes GSK3beta-dependent phosphorylation of beta-catenin, thereby stimulating degradation of the beta-catenin. An essential step in that process is the phosphorylation of Axin. Examination of Axin's amino acid sequence revealed it to contain six arginine-X-leucine (RXL) sequences, the cyclin-dependent kinase 2 (CDK2) binding motif, and 10 CDK2 consensus phosphorylation sequences. We also found that cyclin A/CDK2 phosphorylates Axin, thereby enhancing its association with beta-catenin. This suggests that cyclin A/CDK2 is a negative regulator of beta-catenin-mediated signal transduction, which exerts its effects through phosphorylation of Axin."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.03.065"xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.03.065"xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/author | "Lee M.S."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/author | "Lee M.S."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/author | "Park C.S."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/author | "Park C.S."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/author | "Kim S.I."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/author | "Kim S.I."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/author | "Kwon M.S."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/author | "Kwon M.S."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/author | "Jho E.H."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/author | "Jho E.H."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/author | "Song W.K."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/author | "Song W.K."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/pages | "478-483"xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/pages | "478-483"xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/title | "Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin."xsd:string |
| http://purl.uniprot.org/citations/15063782 | http://purl.uniprot.org/core/title | "Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin."xsd:string |