| http://purl.uniprot.org/citations/15064394 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15064394 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15064394 | http://www.w3.org/2000/01/rdf-schema#comment | "Parkinson's disease (PD) is a neurodegenerative disease characterized by Lewy body formation and death of dopaminergic neurons. Mutations in alpha-synuclein and parkin cause familial forms of PD. Synphilin-1 was shown to interact with alpha-synuclein and to promote the formation of cytosolic inclusions. We now report that synphilin-1 interacts with the E3 ubiquitin-ligases SIAH-1 and SIAH-2. SIAH proteins ubiquitylate synphilin-1 both in vitro and in vivo, promoting its degradation by the ubiquitin-proteasome system. Inability of the proteasome to degrade synphilin-1/SIAH complex leads to a robust formation of ubiquitylated cytosolic inclusions. Ubiquitylation is required for inclusion formation, because a catalytically inactive mutant of SIAH-1, which still binds to synphilin-1, fails to promote inclusions. Like synphilin-1, alpha-synuclein associates with SIAH in intact cells, but the interaction with SIAH-2 was much stronger that with SIAH-1. In vitro experiments show that SIAH-2 monoubiquitylates alpha-synuclein. Further evidence that SIAH proteins may play a role in inclusion formation comes from the demonstration of SIAH immunoreactivity in Lewy bodies of PD patients."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0401081101"xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0401081101"xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Riess O."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Riess O."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Ross C.A."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Ross C.A."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Rott R."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Rott R."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Engelender S."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Engelender S."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Berg D."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Berg D."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Shemer R."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Shemer R."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Szargel R."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Szargel R."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Bornemann A."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Bornemann A."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Avraham E."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Avraham E."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Eyal A."xsd:string |
| http://purl.uniprot.org/citations/15064394 | http://purl.uniprot.org/core/author | "Eyal A."xsd:string |