| http://purl.uniprot.org/citations/15072554 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15072554 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15072554 | http://www.w3.org/2000/01/rdf-schema#comment | "The thymus contains many apoptotic cells that arise from the process of positive and negative selection. Both thymic macrophages and thymic nurse cells/nursing thymic epithelial cells (nursing TECs), non-professional phagocytes, recognize and ingest apoptotic cells without inflammation or tissue damage. Previously we reported that human scavenger receptor class B (SR-B1) is involved in recognition of apoptotic thymocytes by nursing TECs. In this study, we examined the expression and role of a phosphatidylserine receptor (PSR). This receptor is believed to participate in the clearance of apoptotic cells. PSR was strongly expressed in nursing TECs. Transforming growth factor-beta augmented the expression of PSR leading to enhanced binding of apoptotic cells to nursing TECs. In nursing TECs, suppressed expression of human SR-B1 with anti-PSR antibody decreased binding of apoptotic thymocytes to nursing TECs. Our results suggest that both PSR and SR-B1 are expressed in nursing TECs and these receptors appear to play a major role in the clearance of apoptotic cells from the thymus."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.org/dc/terms/identifier | "doi:10.1677/jme.0.0320497"xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.org/dc/terms/identifier | "doi:10.1677/jme.0.0320497"xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Abe H."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Abe H."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Imachi H."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Imachi H."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Ishida T."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Ishida T."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Murao K."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Murao K."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Takahara J."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Takahara J."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Wong N.C.W."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Wong N.C.W."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Cao W.M."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Cao W.M."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Dobashi H."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Dobashi H."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Hiramine C."xsd:string |
| http://purl.uniprot.org/citations/15072554 | http://purl.uniprot.org/core/author | "Hiramine C."xsd:string |