| http://purl.uniprot.org/citations/15082529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15082529 | http://www.w3.org/2000/01/rdf-schema#comment | "The establishment of DNA synthesis during the S phase is a multistep process that occurs in several stages beginning in late mitosis. The first step is the formation of a large prereplicative complex (pre-RC) at individual replication origins and occurs during exit from mitosis and entry into G1 phase. To better understand the genetic requirements for pre-RC formation, we selected chromosomal suppressors of a temperature-sensitive cdc6-4 mutant defective for pre-RC assembly. Loss-of-function mutations in the chromatin-modifying genes SIR2, and to a lesser extent in SIR3 and SIR4, suppressed the cdc6-4 temperature-sensitive lethality. This suppression was independent of the well-known silencing roles for the SIR proteins at the HM loci, at telomeres, or at the rDNA locus. A deletion of SIR2 uniquely rescued both the DNA synthesis defect of the cdc6-4 mutant and its severe plasmid instability phenotype for many origins. A SIR2 deletion suppressed additional initiation mutants affecting pre-RC assembly but not mutants that act subsequently. These findings suggest that Sir2p negatively regulates the initiation of DNA replication through a novel mechanism and reveal another connection between proteins that initiate DNA synthesis and those that establish silent heterochromatin in budding yeast."xsd:string |
| http://purl.uniprot.org/citations/15082529 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1173204"xsd:string |
| http://purl.uniprot.org/citations/15082529 | http://purl.uniprot.org/core/author | "Weinreich M."xsd:string |
| http://purl.uniprot.org/citations/15082529 | http://purl.uniprot.org/core/author | "Pappas D.L. Jr."xsd:string |
| http://purl.uniprot.org/citations/15082529 | http://purl.uniprot.org/core/author | "Frisch R."xsd:string |
| http://purl.uniprot.org/citations/15082529 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15082529 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/15082529 | http://purl.uniprot.org/core/pages | "769-781"xsd:string |
| http://purl.uniprot.org/citations/15082529 | http://purl.uniprot.org/core/title | "The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication."xsd:string |
| http://purl.uniprot.org/citations/15082529 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/15082529 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15082529 |
| http://purl.uniprot.org/citations/15082529 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15082529 |
| http://purl.uniprot.org/uniprot/P06700#attribution-5EC08470B91A296C572F16838CE2F304 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15082529 |
| http://purl.uniprot.org/uniprot/#_P09119-mappedCitation-15082529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15082529 |
| http://purl.uniprot.org/uniprot/#_P06700-mappedCitation-15082529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15082529 |
| http://purl.uniprot.org/uniprot/#_P06701-mappedCitation-15082529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15082529 |
| http://purl.uniprot.org/uniprot/#_P11978-mappedCitation-15082529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15082529 |
| http://purl.uniprot.org/uniprot/P09119 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15082529 |
| http://purl.uniprot.org/uniprot/P06701 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15082529 |
| http://purl.uniprot.org/uniprot/P11978 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15082529 |
| http://purl.uniprot.org/uniprot/P06700 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15082529 |