| http://purl.uniprot.org/citations/15086532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15086532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15086532 | http://www.w3.org/2000/01/rdf-schema#comment | "During the past few years several new interacting partners for G protein-coupled receptors (GPCRs) have been discovered, suggesting that the activity of these receptors is more complex than previously anticipated. Recently, candidate G protein-coupled receptor associated sorting protein (GASP-1) has been identified as a novel interacting partner for the delta opioid receptor and has been proposed to determine the degradative fate of this receptor. We show here that GASP-1 associates in vitro with other opioid receptors and that the interaction domain in these receptors is restricted to a small portion of the carboxyl-terminal tail, corresponding to helix 8 in the three-dimensional structure of rhodopsin. In addition, we show that GASP-1 interacts with COOH-terminus of several other GPCRs from subfamilies A and B and that two conserved residues within the putative helix 8 of these receptors are critical for the interaction with GASP-1. In situ hybridization and northern blot analysis indicate that GASP-1 mRNA is mainly distributed throughout the central nervous system, consistent with a potential interaction with numerous GPCRs in vivo. Finally, we show that GASP-1 is a member of a novel family comprising at least 10 members, whose genes are clustered on chromosome X. Another member of the family, GASP-2, also interacts with the carboxyl-terminal tail of several GPCRs. Therefore, GASP proteins may represent an important protein family regulating GPCR physiology."xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2004.02411.x"xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2004.02411.x"xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/author | "Boeuf J.J.-M."xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/author | "Boeuf J.J.-M."xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/author | "Karcher P."xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/author | "Karcher P."xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/author | "Kieffer B.L."xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/author | "Kieffer B.L."xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/author | "Matifas A."xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/author | "Matifas A."xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/author | "Simonin F."xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/author | "Simonin F."xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/pages | "766-775"xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/pages | "766-775"xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/title | "Identification of a novel family of G protein-coupled receptor associated sorting proteins."xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/title | "Identification of a novel family of G protein-coupled receptor associated sorting proteins."xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/volume | "89"xsd:string |
| http://purl.uniprot.org/citations/15086532 | http://purl.uniprot.org/core/volume | "89"xsd:string |