| http://purl.uniprot.org/citations/15096536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15096536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15096536 | http://www.w3.org/2000/01/rdf-schema#comment | "The complement system is an essential component of host defense against pathogens. Previous research in our laboratory identified StcE, a metalloprotease secreted by Escherichia coli O157:H7 that cleaves the serpin C1 esterase inhibitor (C1-INH), a major regulator of the classical complement cascade. Analyses of StcE-treated C1-INH activity revealed that surprisingly, StcE enhanced the ability of C1-INH to inhibit the classical complement-mediated lysis of sheep erythrocytes. StcE directly interacts with both cells and C1-INH, thereby binding C1-INH to the cell surface. This suggests that the augmented activity of StcE-treated C1-INH is due to the increased concentration of C1-INH at the sites of potential lytic complex formation. Indeed, removal of StcE abolishes the ability of C1-INH to bind erythrocyte surfaces, whereas the proteolysis of C1-INH is unnecessary to potentiate its inhibitory activity. Physical analyses showed that StcE interacts with C1-INH within its aminoterminal domain, allowing the unaffected serpin domain to interact with its targets. In addition, StcE-treated C1-INH provides significantly increased serum resistance to E. coli K-12 over native C1-INH. These data suggest that by recruiting C1-INH to cell surfaces, StcE may protect both E. coli O157:H7 and the host cells to which the bacterium adheres from complement-mediated lysis and potentially damaging inflammatory events."xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20030255"xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20030255"xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/author | "Welch R.A."xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/author | "Welch R.A."xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/author | "Bergsbaken T."xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/author | "Bergsbaken T."xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/author | "Lathem W.W."xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/author | "Lathem W.W."xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/pages | "1077-1087"xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/pages | "1077-1087"xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/title | "Potentiation of C1 esterase inhibitor by StcE, a metalloprotease secreted by Escherichia coli O157:H7."xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/title | "Potentiation of C1 esterase inhibitor by StcE, a metalloprotease secreted by Escherichia coli O157:H7."xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/volume | "199"xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://purl.uniprot.org/core/volume | "199"xsd:string |
| http://purl.uniprot.org/citations/15096536 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15096536 |
| http://purl.uniprot.org/citations/15096536 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15096536 |
| http://purl.uniprot.org/citations/15096536 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15096536 |
| http://purl.uniprot.org/citations/15096536 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15096536 |