| http://purl.uniprot.org/citations/15107404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15107404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15107404 | http://www.w3.org/2000/01/rdf-schema#comment | "Liver tumor cells arise from normal hepatocytes that escape negative control of proliferation. The transcription factor C/EBPalpha maintains quiescence of hepatocytes through two pathways: inhibition of cdks and repression of E2F. Nevertheless, liver tumors and cultured hepatoma cell lines proliferate in the presence of C/EBPalpha. In this paper, we present evidence that the activation of the PI3K/Akt pathway in liver tumor cells blocks the growth inhibitory activity of C/EBPalpha through the PP2A-mediated dephosphorylation of C/EBPalpha on Ser 193, leading to a failure of C/EBPalpha to interact with and inhibit cdks and E2F. Mutation of Ser 193 to Ala also abolishes the ability of C/EBPalpha to cause growth arrest because of a lack of interactions with cdk2 and E2F-Rb complexes. These data provide a molecular basis for the development of liver tumors in which the activation of PI3K/Akt pathway neutralizes C/EBPalpha growth inhibitory activity."xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1183304"xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1183304"xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/author | "Wang G.L."xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/author | "Wang G.L."xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/author | "Timchenko N.A."xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/author | "Timchenko N.A."xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/author | "Awad S."xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/author | "Awad S."xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/author | "Iakova P."xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/author | "Iakova P."xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/author | "Wilde M."xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/author | "Wilde M."xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/pages | "912-925"xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/pages | "912-925"xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/title | "Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity."xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/title | "Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity."xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/15107404 | http://purl.uniprot.org/core/volume | "18"xsd:string |