| http://purl.uniprot.org/citations/15133481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15133481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15133481 | http://www.w3.org/2000/01/rdf-schema#comment | "Both heterotypic and homotypic fusion events are required to deliver endocytosed macromolecules to lysosomes and remodel late endocytic organelles. A trans-SNARE complex consisting of Q-SNAREs syntaxin 7, Vti1b and syntaxin 8 and the R-SNARE VAMP8 has been shown by others to be responsible for homotypic fusion of late endosomes. Using antibody inhibition experiments in rat liver cell-free systems, we confirmed this result, but found that the same Q-SNAREs can combine with an alternative R-SNARE, namely VAMP7, for heterotypic fusion between late endosomes and lysosomes. Co-immunoprecipitation demonstrated separate syntaxin 7 complexes with either VAMP7 or VAMP8 in solubilized rat liver membranes. Additionally, overexpression of the N-terminal domain of VAMP7, in cultured fibroblastic cells, inhibited the mixing of a preloaded lysosomal content marker with a marker delivered to late endosomes. These data show that combinatorial interactions of SNAREs determine whether late endosomes undergo homotypic or heterotypic fusion events."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.7400150"xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.7400150"xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "James D.E."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "James D.E."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Lindsay M.R."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Lindsay M.R."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Stewart A."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Stewart A."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Luzio J.P."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Luzio J.P."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Piper R.C."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Piper R.C."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Bright N.A."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Bright N.A."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Gray S.R."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Gray S.R."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Pryor P.R."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Pryor P.R."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Mullock B.M."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Mullock B.M."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Richardson S.C.W."xsd:string |
| http://purl.uniprot.org/citations/15133481 | http://purl.uniprot.org/core/author | "Richardson S.C.W."xsd:string |