| http://purl.uniprot.org/citations/15175761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15175761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15175761 | http://www.w3.org/2000/01/rdf-schema#comment | "Calorie restriction extends lifespan in organisms ranging from yeast to mammals. In yeast, the SIR2 gene mediates the life-extending effects of calorie restriction. Here we show that the mammalian SIR2 orthologue, Sirt1 (sirtuin 1), activates a critical component of calorie restriction in mammals; that is, fat mobilization in white adipocytes. Upon food withdrawal Sirt1 protein binds to and represses genes controlled by the fat regulator PPAR-gamma (peroxisome proliferator-activated receptor-gamma), including genes mediating fat storage. Sirt1 represses PPAR-gamma by docking with its cofactors NCoR (nuclear receptor co-repressor) and SMRT (silencing mediator of retinoid and thyroid hormone receptors). Mobilization of fatty acids from white adipocytes upon fasting is compromised in Sirt1+/-mice. Repression of PPAR-gamma by Sirt1 is also evident in 3T3-L1 adipocytes, where overexpression of Sirt1 attenuates adipogenesis, and RNA interference of Sirt1 enhances it. In differentiated fat cells, upregulation of Sirt1 triggers lipolysis and loss of fat. As a reduction in fat is sufficient to extend murine lifespan, our results provide a possible molecular pathway connecting calorie restriction to life extension in mammals."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature02583"xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature02583"xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Guarente L."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Guarente L."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Picard F."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Picard F."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "McBurney M.W."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "McBurney M.W."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Leid M."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Leid M."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Senawong T."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Senawong T."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Chung N."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Chung N."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Kurtev M."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Kurtev M."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Machado De Oliveira R."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Machado De Oliveira R."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Topark-Ngarm A."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/author | "Topark-Ngarm A."xsd:string |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15175761 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |