| http://purl.uniprot.org/citations/15208624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15208624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15208624 | http://www.w3.org/2000/01/rdf-schema#comment | "Intracellular double-stranded RNA (dsRNA) is a chief sign of replication for many viruses. Host mechanisms detect the dsRNA and initiate antiviral responses. In this report, we identify retinoic acid inducible gene I (RIG-I), which encodes a DExD/H box RNA helicase that contains a caspase recruitment domain, as an essential regulator for dsRNA-induced signaling, as assessed by functional screening and assays. A helicase domain with intact ATPase activity was responsible for the dsRNA-mediated signaling. The caspase recruitment domain transmitted 'downstream' signals, resulting in the activation of transcription factors NF-kappaB and IRF-3. Subsequent gene activation by these factors induced antiviral functions, including type I interferon production. Thus, RIG-I is key in the detection and subsequent eradication of the replicating viral genomes."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1087"xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1087"xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Imaizumi T."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Imaizumi T."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Kikuchi M."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Kikuchi M."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Taira K."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Taira K."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Yoneyama M."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Yoneyama M."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Miyagishi M."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Miyagishi M."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Natsukawa T."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Natsukawa T."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Shinobu N."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/author | "Shinobu N."xsd:string |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15208624 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |