| http://purl.uniprot.org/citations/15211577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15211577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15211577 | http://www.w3.org/2000/01/rdf-schema#comment | "Hydrogen peroxide-inducible clone-5 (Hic-5), belongs to the group III LIM domain protein family and contains four carboxyl-terminal LIM domains (LIM1-LIM4). In addition to its role in focal adhesion signaling, Hic-5 acts in the nucleus as a coactivator for some steroid hormone receptors such as the glucocorticoid receptor (GR) and androgen receptor (AR). Based upon its effect on AR transactivation, Hic-5 has also been designated as ARA55. Here, we report mapping studies of Hic-5/ARA55 functional domains and establish that LIM3 and LIM4 are necessary for maximal effects on GR transactivation. However, results from yeast two-hybrid assays demonstrated that these two LIM domains together, while necessary, are not sufficient to interact with the tau2 transactivation domain of GR. LIM4 also functions as a nuclear matrix targeting sequence (NMTS) for Hic-5/ARA55, as it is both necessary and sufficient to target a heterologous protein to the nuclear matrix. Thus, as suggested from previous analysis of LIM domain-containing proteins, separate but highly related LIM domains serve distinct functions."xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.20109"xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.20109"xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/author | "Stallcup M.R."xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/author | "Stallcup M.R."xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/author | "Guerrero-Santoro J."xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/author | "Guerrero-Santoro J."xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/author | "DeFranco D.B."xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/author | "DeFranco D.B."xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/pages | "810-819"xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/pages | "810-819"xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/title | "Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation."xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/title | "Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation."xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/volume | "92"xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://purl.uniprot.org/core/volume | "92"xsd:string |
| http://purl.uniprot.org/citations/15211577 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15211577 |
| http://purl.uniprot.org/citations/15211577 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15211577 |