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http://purl.uniprot.org/citations/15219805http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15219805http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15219805http://www.w3.org/2000/01/rdf-schema#comment"Vascular smooth muscle cells (SMC) play an important role in atherogenesis and vasospasm. Interferon-gamma (IFN-gamma) is a potent cytokine that regulates immune and inflammatory responses by inducing multiple genes in many types of cells including SMC. Retinoic acid-inducible gene-I (RIG-I) is a putative RNA helicase, but its physiological function is not known. RIG-I is induced in leukemic cells by retinoic acid or in endothelial cells by lipopolysaccharide. We have studied the expression of RIG-I in cultured SMC from human umbilical artery. IFN-gamma stimulated SMC to express RIG-I mRNA and protein in concentration- and time-dependent manners. Immunohistochemical analysis revealed the expression of RIG-I in SMC in vivo. We conclude that RIG-I may play some pathophysiological role in immune and inflammatory reactions in SMC."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.org/dc/terms/identifier"doi:10.1016/j.lfs.2004.01.030"xsd:string
http://purl.uniprot.org/citations/15219805http://purl.org/dc/terms/identifier"doi:10.1016/j.lfs.2004.01.030"xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Inoue I."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Inoue I."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Ishikawa A."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Ishikawa A."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Fujita T."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Fujita T."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Satoh K."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Satoh K."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Yoshida H."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Yoshida H."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Yamashita K."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Yamashita K."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Imaizumi T."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Imaizumi T."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Hatakeyama M."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Hatakeyama M."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Yagihashi S."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Yagihashi S."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Taima K."xsd:string
http://purl.uniprot.org/citations/15219805http://purl.uniprot.org/core/author"Taima K."xsd:string