| http://purl.uniprot.org/citations/15220916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15220916 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanism by which mutations in CARD15, which encodes nucleotide-binding oligomerization domain 2 (NOD2), cause Crohn disease is poorly understood. Because signaling via mutated NOD2 proteins leads to defective activation of the transcription factor NF-kappa B, one proposal is that mutations cause deficient NF-kappa B-dependent T helper type 1 (T(H)1) responses and increased susceptibility to infection. However, this idea is inconsistent with the increased T(H)1 responses characteristic of Crohn disease. Here we used Card15(-/-) mice to show that intact NOD2 signaling inhibited Toll-like receptor 2-driven activation of NF-kappa B, particularly of the NF-kappa B subunit c-Rel. Moreover, NOD2 deficiency or the presence of a Crohn disease-like Card15 mutation increased Toll-like receptor 2-mediated activation of NF-kappa B-c-Rel, and T(H)1 responses were enhanced. Thus, CARD15 mutations may lead to disease by causing excessive T(H)1 responses."xsd:string |
| http://purl.uniprot.org/citations/15220916 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1092"xsd:string |
| http://purl.uniprot.org/citations/15220916 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/15220916 | http://purl.uniprot.org/core/author | "Murray P.J."xsd:string |
| http://purl.uniprot.org/citations/15220916 | http://purl.uniprot.org/core/author | "Strober W."xsd:string |
| http://purl.uniprot.org/citations/15220916 | http://purl.uniprot.org/core/author | "Kitani A."xsd:string |
| http://purl.uniprot.org/citations/15220916 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15220916 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/15220916 | http://purl.uniprot.org/core/pages | "800-808"xsd:string |
| http://purl.uniprot.org/citations/15220916 | http://purl.uniprot.org/core/title | "NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses."xsd:string |
| http://purl.uniprot.org/citations/15220916 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/15220916 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15220916 |
| http://purl.uniprot.org/citations/15220916 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15220916 |
| http://purl.uniprot.org/uniprot/P97378#attribution-35165AE2893BD6634788CD74D2A52803 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220916 |
| http://purl.uniprot.org/uniprot/Q60837#attribution-35165AE2893BD6634788CD74D2A52803 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220916 |
| http://purl.uniprot.org/uniprot/P18893#attribution-35165AE2893BD6634788CD74D2A52803 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220916 |
| http://purl.uniprot.org/uniprot/P43431#attribution-35165AE2893BD6634788CD74D2A52803 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220916 |
| http://purl.uniprot.org/uniprot/P43431#attribution-C727CFC6BBBFDE22701EFCF3B0CC7042 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220916 |
| http://purl.uniprot.org/uniprot/P43432#attribution-35165AE2893BD6634788CD74D2A52803 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220916 |
| http://purl.uniprot.org/uniprot/P43432#attribution-C727CFC6BBBFDE22701EFCF3B0CC7042 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220916 |
| http://purl.uniprot.org/uniprot/Q8K3Z0#attribution-0DC973E410EA8059A90F70E5067167BE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220916 |
| http://purl.uniprot.org/uniprot/Q8K3Z0#attribution-35165AE2893BD6634788CD74D2A52803 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220916 |
| http://purl.uniprot.org/uniprot/P25799#attribution-35165AE2893BD6634788CD74D2A52803 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220916 |
| http://purl.uniprot.org/uniprot/P25799#attribution-C727CFC6BBBFDE22701EFCF3B0CC7042 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15220916 |