| http://purl.uniprot.org/citations/15274919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15274919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15274919 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the Lis1 gene result in lissencephaly (smooth brain), a debilitating developmental syndrome caused by the impaired ability of postmitotic neurons to migrate to their correct destination in the cerebral cortex. Sequence similarities suggest that the LIS1 protein contains a C-terminal seven-blade beta-propeller domain, while the structure of the N-terminal fragment includes the LisH (Lis-homology) motif, a pattern found in over 100 eukaryotic proteins with a hitherto unknown function. We present the 1.75 A resolution crystal structure of the N-terminal domain of mouse LIS1, and we show that the LisH motif is a novel, thermodynamically very stable dimerization domain. The structure explains the molecular basis of a low severity form of lissencephaly."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2004.03.024"xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2004.03.024"xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Cooper D.R."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Cooper D.R."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Derewenda U."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Derewenda U."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Derewenda Z.S."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Derewenda Z.S."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Otlewski J."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Otlewski J."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Oleksy A."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Oleksy A."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Devedjiev Y."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Devedjiev Y."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Kim M.-H."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Kim M.-H."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Reiner O."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/author | "Reiner O."xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/15274919 | http://purl.uniprot.org/core/name | "Structure"xsd:string |