| http://purl.uniprot.org/citations/15314207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15314207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15314207 | http://www.w3.org/2000/01/rdf-schema#comment | "Active cytoplasmic RNA localization depends on the attachment of RNA-binding proteins that dictate the destination of the RNA molecule. In this study, we used an electrophoretic mobility-shift assay in combination with equilibrium and kinetic analyses to characterize the assembly of the human zipcode-binding protein IMP1 on targets in the 3'-UTR from Igf-II mRNA and in H19 RNA. In both cases, two molecules of IMP1 bound to RNA by a sequential, cooperative mechanism, characterized by an initial fast step, followed by a slow second step. The first step created an obligatory assembly intermediate of low stability, whereas the second step was the discriminatory event that converted a putative RNA target into a 'locked' stable RNP. The ability to dimerize was also observed between members of the IMP family of zipcode-binding proteins, providing a multitude of further interaction possibilities within RNP granules and with the localization apparatus."xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkh754"xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkh754"xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/author | "Willemoes M."xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/author | "Willemoes M."xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/author | "Nielsen J."xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/author | "Nielsen J."xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/author | "Christiansen J."xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/author | "Christiansen J."xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/author | "Nielsen F.C."xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/author | "Nielsen F.C."xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/author | "Kristensen M.A."xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/author | "Kristensen M.A."xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/pages | "4368-4376"xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/pages | "4368-4376"xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/title | "Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability."xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/title | "Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability."xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/15314207 | http://purl.uniprot.org/core/volume | "32"xsd:string |