| http://purl.uniprot.org/citations/15327775 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15327775 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15327775 | http://www.w3.org/2000/01/rdf-schema#comment | "In mammals, heterochromatin is characterized by DNA methylation at CpG dinucleotides and methylation at lysine 9 of histone H3. It is currently unclear whether there is a coordinated transmission of these two epigenetic modifications through DNA replication. Here we show that the methyl-CpG binding protein MBD1 forms a stable complex with histone H3-K9 methylase SETDB1. Moreover, during DNA replication, MBD1 recruits SETDB1 to the large subunit of chromatin assembly factor CAF-1 to form an S phase-specific CAF-1/MBD1/SETDB1 complex that facilitates methylation of H3-K9 during replication-coupled chromatin assembly. In the absence of MBD1, H3-K9 methylation is lost at multiple genomic loci and results in activation of p53BP2 gene, normally repressed by MBD1 in HeLa cells. Our data suggest a model in which H3-K9 methylation by SETDB1 is dependent on MBD1 and is heritably maintained through DNA replication to support the formation of stable heterochromatin at methylated DNA."xsd:string |
| http://purl.uniprot.org/citations/15327775 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2004.06.043"xsd:string |
| http://purl.uniprot.org/citations/15327775 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2004.06.043"xsd:string |
| http://purl.uniprot.org/citations/15327775 | http://purl.uniprot.org/core/author | "Sarraf S.A."xsd:string |
| http://purl.uniprot.org/citations/15327775 | http://purl.uniprot.org/core/author | "Sarraf S.A."xsd:string |
| http://purl.uniprot.org/citations/15327775 | http://purl.uniprot.org/core/author | "Stancheva I."xsd:string |
| http://purl.uniprot.org/citations/15327775 | http://purl.uniprot.org/core/author | "Stancheva I."xsd:string |
| http://purl.uniprot.org/citations/15327775 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15327775 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15327775 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15327775 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15327775 | http://purl.uniprot.org/core/pages | "595-605"xsd:string |
| http://purl.uniprot.org/citations/15327775 | http://purl.uniprot.org/core/pages | "595-605"xsd:string |
| http://purl.uniprot.org/citations/15327775 | http://purl.uniprot.org/core/title | "Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly."xsd:string |
| http://purl.uniprot.org/citations/15327775 | http://purl.uniprot.org/core/title | "Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly."xsd:string |
| http://purl.uniprot.org/citations/15327775 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/15327775 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/15327775 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15327775 |
| http://purl.uniprot.org/citations/15327775 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15327775 |
| http://purl.uniprot.org/citations/15327775 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15327775 |
| http://purl.uniprot.org/citations/15327775 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15327775 |
| http://purl.uniprot.org/uniprot/Q13111 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15327775 |
| http://purl.uniprot.org/uniprot/Q15047 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15327775 |