| http://purl.uniprot.org/citations/15334074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15334074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15334074 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling through the second messengers calcium and diacylglycerol (DAG) is a critical element in many biological systems. Integration of calcium and DAG signals has been suggested to occur primarily through protein kinase C family members, which bind both calcium and DAG. However, an alternative pathway may involve members of the CalDAG-GEF/RasGRP protein family, which have structural features (calcium-binding EF hands and DAG-binding C1 domains) that suggest they can function in calcium and DAG signal integration. To gain insight into the signaling systems that may be regulated by CalDAG-GEF/RasGRP family members, we have focused on CalDAG-GEFI, which is expressed preferentially in the brain and blood. Through genetic ablation in the mouse, we have found that CalDAG-GEFI is crucial for signal integration in platelets. Mouse platelets that lack CalDAG-GEFI are severely compromised in integrin-dependent aggregation as a consequence of their inability to signal through CalDAG-GEFI to its target, the small GTPase Rap1. These results suggest that analogous signaling defects are likely to occur in the central nervous system when CalDAG-GEFI is absent or compromised in function."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm1098"xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm1098"xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Liang Y."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Liang Y."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Bergmeier W."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Bergmeier W."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Piffath C.L."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Piffath C.L."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Wagner D.D."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Wagner D.D."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Housman D.E."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Housman D.E."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Crittenden J.R."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Crittenden J.R."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Graybiel A.M."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/author | "Graybiel A.M."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/name | "Nat. Med."xsd:string |
| http://purl.uniprot.org/citations/15334074 | http://purl.uniprot.org/core/name | "Nat. Med."xsd:string |