| http://purl.uniprot.org/citations/15355978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15355978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15355978 | http://www.w3.org/2000/01/rdf-schema#comment | "Adenomatous polyposis coli (APC) protein and Axin form a complex that mediates the down-regulation of beta-catenin, a key effector of Wnt signaling. Truncation mutations in APC are responsible for familial and sporadic colorectal tumors due to failure in the down-regulation of beta-catenin. While the regulation of beta-catenin by APC has been extensively studied, the regulation of APC itself has received little attention. Here we show that the level of APC is down-regulated by the ubiquitin-proteasome pathway and that Wnt signaling inhibits the process. The domain responsible for the down-regulation and direct ubiquitination was identified. We also show an unexpected role for Axin in facilitating the ubiquitination-proteasome-mediated down-regulation of APC through the oligomerization of Axin. Our results suggest a new mechanism for the regulation of APC by Axin and Wnt signaling."xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m404655200"xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m404655200"xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/author | "Park S.Y."xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/author | "Park S.Y."xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/author | "Choi J."xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/author | "Choi J."xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/author | "Costantini F."xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/author | "Costantini F."xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/author | "Jho E.-H."xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/author | "Jho E.-H."xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/author | "Joo C.-K."xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/author | "Joo C.-K."xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/pages | "49188-49198"xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/pages | "49188-49198"xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/title | "Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin."xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/title | "Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin."xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15355978 | http://purl.uniprot.org/core/volume | "279"xsd:string |