| http://purl.uniprot.org/citations/15365179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15365179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15365179 | http://www.w3.org/2000/01/rdf-schema#comment | "Simple (i.e., nonstratified) epithelial cells use two different routes to target their newly synthesized luminal plasma membrane proteins to the cell surface: a direct route from the Golgi complex, as in the kidney-derived MDCK cell line, or an indirect route that involves a intermediate stop at the ab-luminal (basolateral) membrane, as in hepatocytes. The mechanisms or proteins responsible for these different protein targeting strategies are not known. Here, we show that increased expression of EMK1, a mammalian ortholog of Caenorhabditis elegans Par-1, in MDCK cells promotes a switch from a direct to a transcytotic mode of apical protein delivery and other trafficking changes typical of hepatocytes. These results, together with our recent demonstration that PAR-1 promotes morphological features of hepatocytes in MDCK cells, indicate that Par-1 modulates the developmental decision to build a columnar versus a hepatic epithelial cell. To our knowledge, Par-1 is the first gene assigned to this task in epithelial morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0403684101"xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0403684101"xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/author | "Cohen D."xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/author | "Cohen D."xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/author | "Rodriguez-Boulan E."xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/author | "Rodriguez-Boulan E."xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/author | "Musch A."xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/author | "Musch A."xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/pages | "13792-13797"xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/pages | "13792-13797"xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/title | "Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells."xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/title | "Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells."xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/15365179 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15365179 |
| http://purl.uniprot.org/citations/15365179 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15365179 |
| http://purl.uniprot.org/citations/15365179 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15365179 |
| http://purl.uniprot.org/citations/15365179 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15365179 |