| http://purl.uniprot.org/citations/15375751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15375751 | http://www.w3.org/2000/01/rdf-schema#comment | "P-cadherin, a transmembrane molecule similar to E-cadherin involved in the cell-cell adhesion, and catenins form complexes between its cytoplasmic domain and the cytoskeleton. Five cell lines, 108 specimens of oral squamous cell carcinomas (OSCC), 9 metastasis and 10 of normal oral mucosa were examined to evaluate P-cadherin expression and cellular localization by immunohistochemistry and western-blotting. In normal oral mucosa there was a membranous expression only in basal and parabasal layers. 91 cases (84%) showed membranous/cytoplasmic positivity, whereas 17 cases (16%) were negative. In particular, while well-differentiated carcinomas showed P-cadherin upregulation, the protein was homogeneously hypo- or unexpressed in low-differentiated carcinomas. There was a statistically significant correlation between P-cadherin expression and tumour grading: G3 tumours had a lower score than G1-G2 tumours (P<0.05). When analysed for prognostic significance, patients with no P-cadherin expression (score 0) had poorer overall and diseases-free survival rates than the P-cadherin-expressing group (score 1) (P=0.0463 and P=0.0471, respectively). Western blotting analysis of cell lines and tissue samples confirmed immunohistochemical findings. When cell staining pattern of positive cases was examined, 52 cases showed a prevalent membranous pattern, while 39 had a prevalent cytoplasmic pattern. Cases with prevalent cytoplasmic staining showed high rates of lymph node metastases (P>0.05), and regional relapse (P <0.05) and poorer survival rates than the group with prevalent membranous expression (P<0.0001). An absent P-cadherin expression could constitute a hallmark of aggressive biological behaviour in oral squamous cell carcinoma."xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.org/dc/terms/identifier | "doi:10.14670/hh-19.1089"xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/author | "Mariggio M.A."xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/author | "De Rosa G."xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/author | "Lo Muzio L."xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/author | "Bufo P."xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/author | "Rubini C."xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/author | "Pannone G."xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/author | "Piattelli A."xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/author | "Staibano S."xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/author | "Mignogna M.D."xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/author | "Procaccini M."xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/author | "Dolci M."xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/name | "Histol Histopathol"xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/pages | "1089-1099"xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/title | "P-cadherin expression predicts clinical outcome in oral squamous cell carcinomas."xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/15375751 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15375751 |
| http://purl.uniprot.org/citations/15375751 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15375751 |
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| http://purl.uniprot.org/uniprot/#_P22223-mappedCitation-15375751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15375751 |
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