| http://purl.uniprot.org/citations/15378032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15378032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15378032 | http://www.w3.org/2000/01/rdf-schema#comment | "Rab5 is a small GTPase that regulates early endosome fusion. We present here the crystal structure of the Rab5 GTPase domain in complex with a GTP analog and the C-terminal domain of effector Rabaptin5. The proteins form a dyad-symmetric Rab5-Rabaptin5(2)-Rab5 ternary complex with a parallel coiled-coil Rabaptin5 homodimer in the middle. Two Rab5 molecules bind independently to the Rabaptin5 dimer using their switch and interswitch regions. The binding does not involve the Rab complementarity-determining regions. We also present the crystal structures of two distinct forms of GDP-Rab5 complexes, both of which are incompatible with Rabaptin5 binding. One has a dislocated and disordered switch I but a virtually intact switch II, whereas the other has its beta-sheet and both switch regions reorganized. Biochemical and functional analyses show that the crystallographically observed Rab5-Rabaptin5 complex also exists in solution, and disruption of this complex by mutation abrogates endosome fusion."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb832"xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb832"xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/author | "Li G."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/author | "Li G."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/author | "Zhu G."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/author | "Zhu G."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/author | "Zhang X.C."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/author | "Zhang X.C."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/author | "Terzyan S."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/author | "Terzyan S."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/author | "Zhai P."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/author | "Zhai P."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/pages | "975-983"xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/pages | "975-983"xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/title | "Structural basis of Rab5-Rabaptin5 interaction in endocytosis."xsd:string |
| http://purl.uniprot.org/citations/15378032 | http://purl.uniprot.org/core/title | "Structural basis of Rab5-Rabaptin5 interaction in endocytosis."xsd:string |