| http://purl.uniprot.org/citations/15388847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15388847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15388847 | http://www.w3.org/2000/01/rdf-schema#comment | "Posttranslational modification by the ubiquitin homologue, small ubiquitin-like modifier 1 (SUMO-1), has been established as an important regulatory mechanism. However, in most cases it is not clear how sumoylation regulates various cellular functions. Emerging evidence suggests that sumoylation may play a general role in regulating protein-protein interactions, as shown in RanBP2/Nup358 and RanGAP1 interaction. In this study, we have defined an amino acid sequence motif that binds SUMO. This motif, V/I-X-V/I-V/I, was identified by NMR spectroscopic characterization of interactions among SUMO-1 and peptides derived from proteins that are known to bind SUMO or sumoylated proteins. This motif binds all SUMO paralogues (SUMO-1-3). Using site-directed mutagenesis, we also show that this SUMO-binding motif in RanBP2/Nup358 is responsible for the interaction between RanBP2/Nup358 and sumoylated RanGAP1. The SUMO-binding motif exists in nearly all proteins known to be involved in SUMO-dependent processes, suggesting its general role in sumoylation-dependent cellular functions."xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0403498101"xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0403498101"xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/author | "Krontiris T.G."xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/author | "Krontiris T.G."xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/author | "Durrin L.K."xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/author | "Durrin L.K."xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/author | "Wilkinson T.A."xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/author | "Wilkinson T.A."xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/pages | "14373-14378"xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/pages | "14373-14378"xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/title | "Identification of a SUMO-binding motif that recognizes SUMO-modified proteins."xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/title | "Identification of a SUMO-binding motif that recognizes SUMO-modified proteins."xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/15388847 | http://purl.uniprot.org/core/volume | "101"xsd:string |