| http://purl.uniprot.org/citations/15454082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15454082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15454082 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcriptional repressor BCL-6 regulates B lymphocyte cell fate during the germinal center reaction by preventing terminal differentiation of B lymphocytes into plasma cells until appropriate signals are received. Here, we report a cofactor, MTA3, a cell type-specific subunit of the corepressor complex Mi-2/NuRD, for BCL-6-dependent cell fate determination. MTA3 is expressed in the same pattern in germinal centers as BCL-6. BCL-6 physically interacts with Mi-2/NuRD and this interaction is sensitive to BCL-6 acetylation status. Depletion of MTA3 by RNAi impairs BCL-6-dependent repression and alters the cell-specific transcriptional pattern characteristic of the B lymphocyte. Remarkably, exogenous expression of BCL-6 in a plasma cell line leads, in an MTA3-dependent manner, to repression of plasma cell-specific transcripts, reactivation of the B cell transcriptional program, expression of B lymphocyte cell surface markers, and reprogramming of cell fate."xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.09.014"xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.09.014"xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/author | "Fujita N."xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/author | "Fujita N."xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/author | "Wade P.A."xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/author | "Wade P.A."xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/author | "Boss J.M."xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/author | "Boss J.M."xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/author | "Akyildiz A."xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/author | "Akyildiz A."xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/author | "Geigerman C."xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/author | "Geigerman C."xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/author | "Jaye D.L."xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/author | "Jaye D.L."xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/author | "Mooney M.R."xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/author | "Mooney M.R."xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/pages | "75-86"xsd:string |
| http://purl.uniprot.org/citations/15454082 | http://purl.uniprot.org/core/pages | "75-86"xsd:string |