| http://purl.uniprot.org/citations/15456759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15456759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15456759 | http://www.w3.org/2000/01/rdf-schema#comment | "Mus musculus Pax2 transactivation domain-interacting protein (Ptip) is an essential gene required for the maintenance of genome stability, although its precise molecular role is unclear. Human PTIP (hPTIP) was recently isolated in a screen for proteins, translated from cDNA pools, capable of interacting with peptides phosphorylated by the ATM (ataxia telangiectasia-mutated)/ATR (ataxia telangiectasia-related) protein kinases. hPTIP was described as a 757-amino acid protein bearing four BRCT domains. Here we report that instead full-length endogenous hPTIP contains 1069 amino acids and six BRCT domains. hPTIP shows increased association with 53BP1 in response to ionizing radiation (IR) but not in response to other DNA-damaging agents. Whereas translocation of both 53BP1 and hPTIP to sites of IR-induced DNA damage occurs independently of ATM, IR-induced association of PTIP and 53BP1 requires ATM. Deletion analysis identified the domains of 53BP1 and hPTIP required for protein-protein interaction and focus formation. Data characterizing the cellular roles of hPTIP are also presented. Small interfering RNA was used to show that hPTIP is required for ATM-mediated phosphorylation of p53 at Ser(15) and for IR-induced up-regulation of the cyclin-dependent kinase inhibitor p21. Lowering hPTIP levels also increased cellular sensitivity to IR, suggesting that this protein plays a critical role in maintaining genome stability."xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m411021200"xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m411021200"xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/author | "Doherty A.J."xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/author | "Doherty A.J."xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/author | "Rouse J."xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/author | "Rouse J."xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/author | "Jowsey P.A."xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/author | "Jowsey P.A."xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/pages | "55562-55569"xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/pages | "55562-55569"xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/title | "Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation."xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/title | "Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation."xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15456759 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15456759 |
| http://purl.uniprot.org/citations/15456759 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15456759 |
| http://purl.uniprot.org/citations/15456759 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15456759 |
| http://purl.uniprot.org/citations/15456759 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15456759 |