| http://purl.uniprot.org/citations/15474514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15474514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15474514 | http://www.w3.org/2000/01/rdf-schema#comment | "VEGFR-3 is essential for vascular development and maintenance of lymphatic vessel's integrity. Little is known about its cooperative effect with other receptors of the same family. Contrary to VEGFR-2, stimulation of VEGFR-3 by VEGF-C and -D failed to enhance its phosphorylation either in HEK293T or in PAE cells. These ligands were unable to induce angiogenesis of PAEC expressing VEGFR-3 alone. In the presence of VEGFR-2, VEGF-C and -D induced heterodimerization of VEGFR-3 with VEGFR-2. This heterodimerization was associated with enhanced VEGFR-3 phosphorylation and subsequent cellular responses as evidenced by the formation of capillary-like structures in PAE cells and proliferation of primary human endothelial cells expressing both receptors. Taken together, these results show for the first time that VEGFR-3 needs to be associated to VEGFR-2 to induce ligand-dependent cellular responses."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.08.237"xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.08.237"xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Alam A."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Alam A."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Carmeliet P."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Carmeliet P."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Bonnin J."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Bonnin J."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Bono F."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Bono F."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Fons P."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Fons P."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Herault J.P."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Herault J.P."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Savi P."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Savi P."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Cassan C."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Cassan C."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Delesque-Touchard N."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Delesque-Touchard N."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Herbert J.M."xsd:string |
| http://purl.uniprot.org/citations/15474514 | http://purl.uniprot.org/core/author | "Herbert J.M."xsd:string |