| http://purl.uniprot.org/citations/1547487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1547487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1547487 | http://www.w3.org/2000/01/rdf-schema#comment | "We have generated mice that carry a germline mutation in which a large portion of the RAG-2 coding region is deleted. Homozygous mutants are viable but fail to produce mature B or T lymphocytes. Very immature lymphoid cells were present in primary lymphoid organs of mutant animals as defined by surface marker analyses and Abelson murine leukemia virus (A-MuLV) transformation assays. However, these cells did not rearrange their immunoglobulin or T cell receptor loci. Lack of V(D)J recombination activity in mutant pre-B cell lines could be restored by introduction of a functional RAG-2 expression vector. Therefore, loss of RAG-2 function in vivo results in total inability to initiate V(D)J rearrangement, leading to a novel severe combined immune deficient (SCID) phenotype. Because the SCID phenotype was the only obvious abnormality detected in RAG-2 mutant mice, RAG-2 function and V(D)J recombinase activity, per se, are not required for development of cells other than lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(92)90029-c"xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(92)90029-c"xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Young F."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Young F."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Mendelsohn M."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Mendelsohn M."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Stall A.M."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Stall A.M."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Shinkai Y."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Shinkai Y."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Datta M."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Datta M."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Alt F.W."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Alt F.W."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Rathbun G."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Rathbun G."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Oltz E.M."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Oltz E.M."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Stewart V."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Stewart V."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Charron J."xsd:string |
| http://purl.uniprot.org/citations/1547487 | http://purl.uniprot.org/core/author | "Charron J."xsd:string |